Peter J. Steinbach
National Institutes of Health
MemExp: Lifetime Distributions via the Maximum Entropy Method
MemExp: Discrete Exponentials via Maximum Likelihood
Welcome to the home page of MemExp and MemDif. MemExp analyzes kinetics data in
terms of distributed and discrete lifetimes, and MemDif analyzes autocorrelation functions obtained from fluorescence correlation spectroscopy in terms of distributed and discrete diffusion times. Both programs provide graphical summaries of the results, estimate the standard errors in the data,
and allow for several `priors' to be considered. By automating a series
of fits by discrete components (exponentials or diffusing species), MemExp and MemDif can be particularly useful when analyzing
data that are appropriately described by multiple components.
For more details and references, please read the documentation. You may also wish to
read about other applications of maximum entropy.
- Download MemExp and/or MemDif. See the summary of revisions.
- Documentation for MemExp 7.0 and MemDif 1.0
- New in MemExp 7.0: Improved estimation of standard errors in simple mode. Additional parameters on command line increase user control in simple mode.
- What was new in Version 6.0:The convolution of the decay with the instrument response function (IRF) is performed using a cubic approximation of the count function for the IRF (Z. Bajzer et al, Biophys J. 81 2001 1765-1775). Additional parameters on command line increase user control in simple mode.
- What was new in Version 5.0: Zero-time shift can now be accounted for when deconvolving an instrument response. Improved automation of fits by discrete exponentials, each fit being initialized based on the recommended distribution (not on different distributions during the MEM run).
- What was new in Version 4.0: New options for adaptation of prior model to suppress artifacts. New 'simple' and 'auto' modes make MemExp easier to use.
- What was new in Version 3.0: True maximum likelihood analysis of Poisson data, deconvolution of instrument response function, correction for scattered excitation light.